Neuropsychological Functions of μ- and δ-Opioid Systems
نویسندگان
چکیده
منابع مشابه
Neuropsychological Functions of μ- and δ-Opioid Systems
Brain opioid innervation is involved in many pathophysiological processes related to drug addiction. The main idea of the present review is that μ-/δ-opioid innervation is an intrinsic component of the motor/approach behavior network, which is activated synergetically with dopaminergic mesocorticolimbic network. Contribution of opioid innervation to the motor/approach behavior processing includ...
متن کاملRegulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5
BACKGROUND AND PURPOSE Phosphorylation of δ opioid receptors (DOP receptors) by cyclin-dependent kinase 5 (CDK5) was shown to regulate the trafficking of this receptor. Therefore, we aimed to determine the role of CDK5 in regulating DOP receptors in rats treated with morphine or with complete Freund's adjuvant (CFA). As μ (MOP) and DOP receptors are known to be co-regulated, we also sought to d...
متن کاملFacilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Codegradation
δ-opioid receptors (DORs) form heteromers with μ-opioid receptors (MORs) and negatively regulate MOR-mediated spinal analgesia. However, the underlying mechanism remains largely unclear. The present study shows that the activity of MORs can be enhanced by preventing MORs from DOR-mediated codegradation. Treatment with DOR-specific agonists led to endocytosis of both DORs and MORs. These recepto...
متن کاملExpression of the μ, κ, and δ-opioid receptors and tyrosine hydroxylase in MN9D cells.
Dopaminergic neurons are suggested to be a critical physiopathology substrate for addiction disorders. It is not well known whether the clonal mesencephalic dopaminergic cell line MN9D cells can be applied to study morphine addiction. Immunofluorescence staining and reverse transcription-polymerase chain reaction (RT-PCR) were used to detect protein and mRNA expression of the μ, κ, and δ-opioid...
متن کاملHeteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor trafficking.
Heteromerization of opioid receptors has been shown to alter opioid receptor pharmacology. However, how receptor heteromerization affects the processes of endocytosis and postendocytic sorting has not been closely examined. This question is of particular relevance for heteromers of the μ-opioid receptor (MOR) and δ-opioid receptor (DOR), because the MOR is recycled primarily after endocytosis a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ISRN Addiction
سال: 2013
ISSN: 2314-4734
DOI: 10.1155/2013/674534